Is the New GLP-1 Pill Better Than Injections?

You may have seen headlines about the new GLP-1 pill and wondered if it’s time to retire your weekly shot. The idea is appealing: no refrigeration, no injection day, no sharps container under the sink. But is it actually better—or just different? For many people, the question isn’t whether GLP-1 medications work; it’s whether the treatment fits their lifestyle. Here, experts answer the most common questions about switching and how the pill compares with injections.

Featured Experts

• Dr. Spencer Nadolsky is an obesity and lipid specialist in Portage, MI
• Melynda Barnes, MD is a board-certified facial plastic surgeon and obesity medicine specialist in New York and chief medical officer at Ro

Who Is a Good Candidate for the GLP-1 Pill?

From a medical standpoint, the answer is straightforward. “The same criteria apply to the oral version as the injection,” says Portage, MI obesity and lipid specialist Dr. Spencer Nadolsky. If you qualify for a GLP-1 injection such as Wegovy, you likely qualify for the pill as well.

New York facial plastic surgeon and obesity medicine specialist Melynda Barnes, MD, chief medical officer at Ro, agrees. “Generally, an appropriate candidate for the Wegovy pill is also eligible for Wegovy in injectable form; it’s more a matter of preference,” she says. “For those who want the benefits of GLP-1 medication and prefer not to use injections, the Wegovy pill is an exciting new, and convenient option, as it doesn’t require refrigeration.”

How the Pill Compares to Weekly Injections

One of the biggest concerns is effectiveness. Is the pill weaker? “People often assume that the Wegovy pill isn’t as effective as injectable GLP-1 medications, but this isn’t the case,” says Dr. Barnes. In clinical trials, the difference was minimal, she says. “People lost 14 percent of their body weight on average with the Wegovy pill and an average of 15 percent on the Wegovy injection.”

Dr. Nadolsky says the oral version is very similar to the injection when it comes to both weight loss and side effects. “It may have slightly less weight loss but pretty similar ballpark,” he notes. “Side effects are similar as well, although some patients like it better and some like it worse.”

Reasons People May Want to Switch

To Avoid Needles

For some patients, this is the entire story. “Some people who dislike needles may like the option,” says Dr. Nadolsky. It also does not require refrigeration, which can make travel and daily logistics easier.

To Minimize After-Shot Side Effects

While the overall side-effect profile is similar to injections, Dr. Nadolsky says some patients feel the pill is better tolerated because it’s taken daily rather than delivered in one larger weekly dose. “Some people have strong side effects one or two days after injection and with the daily dose it seems to be steadier as opposed to a large amount at once,” he explains.

The pill does not eliminate side effects such as nausea or abdominal discomfort, but for some patients, daily dosing can feel more even and predictable.

To Stay on Maintenance Long Term

Once patients reach their goal weight, the conversation shifts. Dr. Barnes notes the pill “can be a great option for those transitioning to maintenance or hoping for a more flexible long-term treatment option.” For some, taking a daily pill feels more sustainable than committing to weekly injections indefinitely.

Dr. Nadolsky sums it up simply: “There will be individual differences.”

What to Know Before Switching

Unlike the weekly injection, the oral GLP-1 comes with specific timing instructions and consistency is key. How you take the pill directly affects how well it works, so following the directions closely matters. Dr. Nadolsky emphasizes that this step is critical for proper absorption. “The medicine needs to be taken on an empty stomach 30 minutes before any more food or water,” he explains. “It needs to be taken with a very small amount of water, four ounces or less.”

That timing can require a routine shift, especially for patients who already take morning medications. “If they’re taking thyroid medicine, the guidance is to take it the night before on an empty stomach as opposed to in the morning,” he adds.